Reduced experimental work by 4 compared to DoE for an oligonucleotide ion exchange process
Customer Success Story from GSK
"GSK Engaged Ypso-Facto’s expertise, their Ypso-Ionic software and GPX approach to develop a mechanistic model of a complex ion-exchange purification process.
Compared with the classical statistical DoE approach, only 25% of the experimental work was required, but we also achieved much more, including deep process understanding, troubleshooting, identification of trends and associated design space as well as multicolumn chromatography predesign.
In addition to the technical project work, Ypso-Facto’s highly collaborative ways of working have increased our organizational expertise and allowed us to demonstrate the value of mechanistic modelling"
Chris MCKAY, Principal Process Engineer, GSK
For more insights on our project with GSK, read these articles:
- Webinar : Getting your process up to speed with digital tools; purification of oligonucleotides by ion exchange chromatography
- Presentation at IOPC 2023 : The benefits of mechanistic modeling to characterize and simulate ion exchange oligonucleotide purification processes
- Poster : Boosting a process with digital tools: Purification of oligonucleotides by ion exchange
